GSTO1

GSTO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EEM, 3LFL, 3VLN, 4IS0
Identifiers
Aliases	GSTO1, GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R, glutathione S-transferase omega 1
External IDs	OMIM: 605482 MGI: 1342273 HomoloGene: 37971 GeneCards: GSTO1
EC number	1.20.4.2
Gene location (Human)
Chr.	Chromosome 10 (human)
End	104,267,459 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	47,853,229 bp
RNA expression pattern
	Top expressed in
	monocyte; ; right lobe of liver; ; right lung; ; middle temporal gyrus; ; kidney tubule; ; left ventricle; ; right ventricle; ; periodontal fiber; ; left adrenal gland; ; endothelial cell;
	Top expressed in
	conjunctival fornix; ; corneal stroma; ; ciliary body; ; gastric mucosa; ; mucous cell of stomach; ; epithelium of stomach; ; superior surface of tongue; ; pyloric antrum; ; duodenum; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; glutathione dehydrogenase (ascorbate) activity; protein binding; methylarsonate reductase activity; oxidoreductase activity; glutathione transferase activity;
Cellular component	cytoplasm; cytosol; extracellular exosome;
Biological process	xenobiotic catabolic process; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; negative regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of ryanodine-sensitive calcium-release channel activity; methylation; cellular response to arsenic-containing substance; positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion; metabolism; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; glutathione derivative biosynthetic process; L-ascorbic acid metabolic process; cellular oxidant detoxification; glutathione metabolic process; toxin catabolic process; interleukin-12-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9446
	14873
	ENSG00000148834
	ENSMUSG00000025068
	P78417; Q5TA02
	O09131
	NM_004832; NM_001191002; NM_001191003
	NM_010362
	NP_001177931; NP_001177932; NP_004823
	NP_034492
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene.

This gene encodes a member of the theta class glutathione S-transferase-like (GSTTL) protein family. In mouse, the encoded protein acts as a small stress response protein, likely involved in cellular redox homeostasis. This protein has dehydroascorbate reductase activity and may function in the glutathione-ascorbate cycle as part of antioxidant metabolism.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.