GNRHR

GNRHR
Identifiers
Aliases	GNRHR, GNRHR1, GRHR, HH7, LHRHR, LRHR, gonadotropin releasing hormone receptor
External IDs	OMIM: 138850 MGI: 95790 HomoloGene: 350 GeneCards: GNRHR
Gene location (Human)
Chr.	Chromosome 4 (human)
End	67,754,388 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	86,345,760 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; ganglionic eminence; ; sural nerve; ; tibialis anterior muscle; ; prefrontal cortex; ; corpus callosum; ; deltoid muscle; ; metanephros; ; Achilles tendon; ; lower lobe of lung;
	Top expressed in
	pituitary gland; ; anterior pituitary; ; right ventricle; ; vastus lateralis muscle; ; digastric muscle; ; spermatid; ; tracheobronchial tree; ; carotid body; ; upper arm; ; skin of abdomen;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein-hormone receptor activity; signal transducer activity; G protein-coupled receptor activity; peptide binding; gonadotropin-releasing hormone receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane; integral component of plasma membrane;
Biological process	multicellular organism development; signal transduction; G protein-coupled receptor signaling pathway; cellular response to gonadotropin-releasing hormone; cellular response to hormone stimulus;
	Sources:Amigo / QuickGO
Orthologs
	2798
	14715
	ENSG00000109163
	ENSMUSG00000029255
	P30968
	Q01776
	NM_001012763; NM_000406
	NM_010323; NM_001310651; NM_001310653
	NP_000397; NP_001012781
	NP_001297580; NP_001297582; NP_034453
	Wikidata
View/Edit Human	View/Edit Mouse

Gonadotropin-releasing hormone receptor is a protein that in humans is encoded by the GNRHR gene.

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

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