Ilomastat

GM6001
Names
	Preferred IUPAC name (3R)-N1-Hydroxy-N4-{(1S)-1-[(1H-indol-3-yl)methyl]-2-(methylamino)-2-oxoethyl}-3-(2-methylpropyl)butanediamide
	Other names Galardin, GM6001
Identifiers
CAS Number	142880-36-2 ;
3D model (JSmol)	Interactive image;
Abbreviations	GM6
ChEBI	CHEBI:137236;
ChemSpider	117009;
DrugBank	DB02255;
MeSH	GM6001
PubChem CID	132519;
UNII	I0403ML141 ;
CompTox Dashboard (EPA)	DTXSID0046353 ;
	InChI InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1;
	SMILES CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NC;
Properties
Chemical formula	C20H28N4O4
Molar mass	388.468 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Ilomastat (INN), (codenamed GM6001, proprietary name Galardin^®) is a broad-spectrum matrix metalloproteinase inhibitor.

This chemotherapy agent is considered to have application in skincare products for its antiaging properties.

Ilomastat is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc.

Examples of enzymes that ilomastat inhibit include rabbit MMP9, thermolysin, peptide deformylase, and anthrax lethal factor endopeptidase (LF) produced by the bacterium Bacillus anthracis.

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