GLMN

GLMN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4F52
Identifiers
Aliases	GLMN, FAP, FAP48, FAP68, FKBPAP, GLML, GVM, VMGLOM, glomulin, FKBP associated protein
External IDs	OMIM: 601749 MGI: 2141180 HomoloGene: 14239 GeneCards: GLMN
Gene location (Human)
Chr.	Chromosome 1 (human)
End	92,298,987 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	107,745,754 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; gastric mucosa; ; Brodmann area 9; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; skin of abdomen; ; cingulate gyrus; ; canal of the cervix; ; Brodmann area 10; ; anterior pituitary;
	Top expressed in
	spermatocyte; ; spermatid; ; secondary oocyte; ; otic placode; ; subclavian artery; ; aortic arch; ; neural tube; ; morula; ; seminiferous tubule; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase inhibitor activity; protein binding; ubiquitin protein ligase binding; hepatocyte growth factor receptor binding;
Cellular component	Cul4A-RING E3 ubiquitin ligase complex; Cul2-RING ubiquitin ligase complex; cullin-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; intracellular anatomical structure; cytoplasm;
Biological process	vasculogenesis; muscle cell differentiation; negative regulation of T cell proliferation; neural tube closure; positive regulation of phosphorylation; circulatory system development; regulation of gene expression, epigenetic; regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	11146
	170823
	ENSG00000174842
	ENSMUSG00000029276
	Q92990
	Q8BZM1
	NM_007070; NM_053274; NM_001319683
	NM_001161738; NM_001161739; NM_133248
	NP_001306612; NP_444504
	NP_001155210; NP_001155211; NP_573511
	Wikidata
View/Edit Human	View/Edit Mouse

Glomulin is a protein that in humans is encoded by the GLMN gene.

This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

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