Fries rearrangement
The Fries rearrangement, named for the German chemist Karl Theophil Fries, is a rearrangement reaction of a phenolic ester to a hydroxy aryl ketone by catalysis of Lewis acids.
| Fries rearrangement | |
|---|---|
| Named after | Karl Theophil Fries |
| Reaction type | Rearrangement reaction |
| Identifiers | |
| Organic Chemistry Portal | fries-rearrangement |
| RSC ontology ID | RXNO:0000444 |
It involves migration of an acyl group of phenol ester to the aryl ring. The reaction is ortho and para selective and one of the two products can be favoured by changing reaction conditions, such as temperature and solvent.
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