Fluticasone furoate

Fluticasone furoate
Clinical data
Trade names	Flonase Sensimist, Veramyst, Arnuity Ellipta, others
AHFS/Drugs.com	Monograph
License data	US DailyMed: Fluticasone furoate;
Pregnancy; category	AU: B3;
Routes of; administration	Intranasal, by mouth
ATC code	R01AD12 (WHO) R03BA09 (WHO) R03AK10 (WHO) R03AL08 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: OTC/ Rx-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	0.51% (Intranasal)
Protein binding	91%
Metabolism	Intranasal; Liver (CYP3A4-mediated)
Elimination half-life	15 hours
Excretion	Kidney
Identifiers
	IUPAC name (6α,11β,16α,17α)-6,9-difluoro-17-{[(fluoro-methyl)thio]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl 2-furancarboxylate;
CAS Number	397864-44-7;
PubChem CID	9854489;
DrugBank	DB08906;
ChemSpider	8030195;
UNII	JS86977WNV;
KEGG	D06315;
ChEBI	CHEBI:74899;
ChEMBL	ChEMBL1676;
CompTox Dashboard (EPA)	DTXSID60228586 ;
ECHA InfoCard	100.158.130
Chemical and physical data
Formula	C27H29F3O6S
Molar mass	538.58 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)SCF)OC(=O)C5=CC=CO5)C)O)F)C)F;
	InChI InChI=1S/C27H29F3O6S/c1-14-9-16-17-11-19(29)18-10-15(31)6-7-24(18,2)26(17,30)21(32)12-25(16,3)27(14,23(34)37-13-28)36-22(33)20-5-4-8-35-20/h4-8,10,14,16-17,19,21,32H,9,11-13H2,1-3H3/t14-,16+,17+,19+,21+,24+,25+,26+,27+/m1/s1; Key:XTULMSXFIHGYFS-VLSRWLAYSA-N;

Fluticasone furoate, sold under the brand name Flonase Sensimist among others, is a corticosteroid for the treatment of non-allergic and allergic rhinitis administered by a nasal spray. It is also available as an inhaled corticosteroid to help prevent and control symptoms of asthma. It is derived from cortisol. Unlike fluticasone propionate, which is only approved for children four years and older, fluticasone furoate is approved in children as young as two years of age when used for allergies.

It was approved for medical use in the United States in April 2007, and in the European Union in November 2008. In 2021, fluticasone was the 23rd most commonly prescribed medication in the United States, with more than 25 million prescriptions.

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