Filaggrin

FLG
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4PCW
Identifiers
Aliases	FLG, ATOD2, filaggrin
External IDs	OMIM: 135940 HomoloGene: 136751 GeneCards: FLG
Gene location (Human)
Chr.	Chromosome 1 (human)
End	152,325,239 bp
RNA expression pattern
	Top expressed in
	human penis; ; vulva; ; nipple; ; skin of abdomen; ; epithelium of esophagus; ; oral cavity; ; amniotic fluid; ; gums; ; sperm; ; cervix epithelium;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; protein binding; structural molecule activity; metal ion binding; transition metal ion binding; structural constituent of skin epidermis;
Cellular component	intermediate filament; keratohyalin granule; intracellular membrane-bounded organelle; nucleus; cytosol; cornified envelope; collagen-containing extracellular matrix;
Biological process	multicellular organism development; keratinocyte differentiation; establishment of skin barrier; cornification; peptide cross-linking;
	Sources:Amigo / QuickGO
Orthologs
	2312
	n/a
	ENSG00000143631
	n/a
	P20930
	n/a
	NM_002016
	n/a
	NP_002007
	n/a
	Wikidata
View/Edit Human

Filaggrin (filament aggregating protein) is a filament-associated protein that binds to keratin fibers in epithelial cells. Ten to twelve filaggrin units are post-translationally hydrolyzed from a large profilaggrin precursor protein during terminal differentiation of epidermal cells. In humans, profilaggrin is encoded by the FLG gene, which is part of the S100 fused-type protein (SFTP) family within the epidermal differentiation complex on chromosome 1q21.

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