Fibronectin

FN1
Available structures
PDB	Ortholog search: H0Y7Z1%20or%20B7ZLE5 PDBe H0Y7Z1,B7ZLE5 RCSB
List of PDB id codes
	1E88, 1E8B, 1FBR, 1FNA, 1FNF, 1FNH, 1J8K, 1O9A, 1OWW, 1Q38, 1QGB, 1QO6, 1TTF, 1TTG, 2CG6, 2CG7, 2CK2, 2CKU, 2EC3, 2FN2, 2FNB, 2GEE, 2H41, 2H45, 2HA1, 2OCF, 2RKY, 2RKZ, 2RL0, 3CAL, 3EJH, 3GXE, 3M7P, 3MQL, 3R8Q, 3ZRZ, 4GH7, 4JE4, 4JEG, 4LXO, 4MMX, 4MMY, 4MMZ, 4PZ5, 2N1K, 5DC4, 5DC0, 5DC9, 3T1W
Identifiers
Aliases	FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, fibronectin 1, SMDCF
External IDs	OMIM: 135600 MGI: 95566 HomoloGene: 1533 GeneCards: FN1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	215,436,073 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	71,692,359 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; right coronary artery; ; synovial membrane; ; ascending aorta; ; tibia; ; stromal cell of endometrium; ; left coronary artery; ; popliteal artery; ; visceral pleura; ; saphenous vein;
	Top expressed in
	calvaria; ; belly cord; ; left lung lobe; ; ankle; ; atrium; ; body of femur; ; uterus; ; ankle joint; ; endocardial cushion; ; cervix;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	heparin binding; collagen binding; integrin binding; protein binding; identical protein binding; peptidase activator activity; protease binding;
Cellular component	blood microparticle; extracellular matrix; fibrinogen complex; extracellular region; basement membrane; apical plasma membrane; extracellular exosome; platelet alpha granule lumen; endoplasmic reticulum-Golgi intermediate compartment; extracellular fluid;
Biological process	regulation of protein phosphorylation; calcium-independent cell-matrix adhesion; endodermal cell differentiation; positive regulation of fibroblast proliferation; positive regulation of substrate-dependent cell migration, cell attachment to substrate; platelet degranulation; extracellular matrix disassembly; wound healing; positive regulation of peptidase activity; peptide cross-linking; cell adhesion; positive regulation of gene expression; acute-phase response; angiogenesis; positive regulation of cell population proliferation; regulation of cell shape; regulation of ERK1 and ERK2 cascade; cell-substrate junction assembly; substrate adhesion-dependent cell spreading; integrin activation; positive regulation of axon extension; cell-matrix adhesion; leukocyte migration; response to wounding; extracellular matrix organization;
	Sources:Amigo / QuickGO
Orthologs
	2335
	14268
	ENSG00000115414
	ENSMUSG00000026193
	P02751
	P11276
NM_001306129; NM_001306130; NM_001306131; NM_001306132; NM_002026;
	NM_054034; NM_212474; NM_212475; NM_212476; NM_212478; NM_212482; NM_001365517; NM_001365518; NM_001365519; NM_001365520; NM_001365521; NM_001365522; NM_001365523; NM_001365524
NM_001276408; NM_001276409; NM_001276410; NM_001276411; NM_001276412;
	NM_001276413; NM_010233
NP_001293058; NP_001293059; NP_001293060; NP_001293061; NP_002017;
	NP_473375; NP_997639; NP_997641; NP_997643; NP_997647; NP_001352446; NP_001352447; NP_001352448; NP_001352449; NP_001352450; NP_001352451; NP_001352452; NP_001352453; NP_001293058.1; NP_001293059.1; NP_001293061.1
NP_001263337; NP_001263338; NP_001263339; NP_001263340; NP_001263341;
	NP_001263342; NP_034363
	Wikidata
View/Edit Human	View/Edit Mouse

Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans).

Fibronectin exists as a protein dimer, consisting of two nearly identical monomers linked by a pair of disulfide bonds. The fibronectin protein is produced from a single gene, but alternative splicing of its pre-mRNA leads to the creation of several isoforms.

Two types of fibronectin are present in vertebrates:

soluble plasma fibronectin (formerly called "cold-insoluble globulin", or CIg) is a major protein component of blood plasma (300 μg/ml) and is produced in the liver by hepatocytes.
insoluble cellular fibronectin is a major component of the extracellular matrix. It is secreted by various cells, primarily fibroblasts, as a soluble protein dimer and is then assembled into an insoluble matrix in a complex cell-mediated process.

Fibronectin plays a major role in cell adhesion, growth, migration, and differentiation, and it is important for processes such as wound healing and embryonic development. Altered fibronectin expression, degradation, and organization has been associated with a number of pathologies, including cancer, arthritis, and fibrosis.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.