Fibroblast growth factor 23

FGF23
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2P39
Identifiers
Aliases	FGF23, ADHR, FGFN, HPDR2, HYPF, PHPTC, fibroblast growth factor 23, HFTC2
External IDs	OMIM: 605380 MGI: 1891427 HomoloGene: 10771 GeneCards: FGF23
Gene location (Human)
Chr.	Chromosome 12 (human)
End	4,379,712 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	127,058,371 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; liver; ; right lobe of liver; ; muscle tissue; ; blood; ; superior frontal gyrus; ; ventricle; ; left ventricle; ; renal cortex; ; lower leg;
	Top expressed in
	superior frontal gyrus; ; extraocular muscle; ; vastus lateralis muscle; ; carotid body; ; major salivary gland; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fibroblast growth factor receptor binding; type 1 fibroblast growth factor receptor binding; growth factor activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity; protein binding;
Cellular component	extracellular region; Golgi lumen; endoplasmic reticulum lumen; extracellular space;
Biological process	cell differentiation; negative regulation of bone mineralization; cellular response to interleukin-6; vitamin D metabolic process; regulation of bone mineralization; phosphate ion homeostasis; cellular phosphate ion homeostasis; response to magnesium ion; regulation of phosphate transport; cellular response to vitamin D; negative regulation of osteoblast differentiation; cellular response to leptin stimulus; positive regulation of transcription, DNA-templated; fibroblast growth factor receptor signaling pathway; response to sodium phosphate; positive regulation of ERK1 and ERK2 cascade; positive regulation of vitamin D 24-hydroxylase activity; phosphate-containing compound metabolic process; vitamin D catabolic process; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; cellular response to parathyroid hormone stimulus; negative regulation of hormone secretion; phosphatidylinositol phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; phosphatidylinositol-3-phosphate biosynthetic process; MAPK cascade; post-translational protein modification; regulation of signaling receptor activity; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	8074
	64654
	ENSG00000118972
	ENSMUSG00000000182
	Q9GZV9
	Q9EPC2
	NM_020638
	NM_022657
	NP_065689
	NP_073148
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 23 (FGF23) is a protein and member of the fibroblast growth factor (FGF) family which participates in the regulation of phosphate in plasma and vitamin D metabolism. In humans it is encoded by the FGF23 gene. FGF23 decreases reabsorption of phosphate in the kidney. Mutations in FGF23 can lead to its increased activity, resulting in autosomal dominant hypophosphatemic rickets.

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