Ferrochelatase
Protoporphyrin ferrochelatase (EC 4.98.1.1, formerly EC 4.99.1.1, or ferrochelatase; systematic name protoheme ferro-lyase (protoporphyrin-forming)) is an enzyme encoded by the FECH gene in humans. Ferrochelatase catalyses the eighth and terminal step in the biosynthesis of heme, converting protoporphyrin IX into heme B. It catalyses the reaction:
- protoheme + 2 H+ = protoporphyrin + Fe2+
| Protoporphyrin ferrochelatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Ferrochelatase homodimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 4.98.1.1 | ||||||||
| CAS no. | 9012-93-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| Ferrochelatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Human ferrochelatase | |||||||||
| Identifiers | |||||||||
| Symbol | Ferrochelatase | ||||||||
| Pfam | PF00762 | ||||||||
| InterPro | IPR001015 | ||||||||
| PROSITE | PDOC00462 | ||||||||
| SCOP2 | 1ak1 / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 129 | ||||||||
| OPM protein | 1hrk | ||||||||
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