Ferritin light chain

FTL
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2FFX, 2FG4, 2FG8, 3KXU
Identifiers
Aliases	FTL, LFTD, NBIA3, ferritin, light polypeptide, ferritin light chain
External IDs	OMIM: 134790 MGI: 5434102 HomoloGene: 79330 GeneCards: FTL
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,966,879 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; blood; ; gallbladder; ; upper lobe of left lung; ; right lung; ; islet of Langerhans; ; subcutaneous adipose tissue; ; spleen; ; monocyte; ; ascending aorta;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	iron ion binding; protein binding; ferric iron binding; metal ion binding; identical protein binding; ferroxidase activity; ferrous iron binding;
Cellular component	cytosol; extracellular exosome; intracellular ferritin complex; membrane; extracellular region; azurophil granule lumen; autolysosome; cytoplasm;
Biological process	iron ion homeostasis; iron ion transport; cellular iron ion homeostasis; intracellular sequestering of iron ion; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	2512
	434624
	ENSG00000087086
	n/a
	P02792
	n/a
	NM_000146
	n/a
	NP_000137
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Ferritin light chain is a protein that in humans is encoded by the FTL gene. Ferritin is the major protein responsible for storing intracellular iron in prokaryotes and eukaryotes. It is a heteropolymer consisting of 24 subunits, heavy and light ferritin chains. This gene has multiple pseudogenes.

It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these assisted reproductive technologies.

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