Factor XIII
Factor XIII or fibrin stabilizing factor is a zymogen found in blood of humans and some other animals. It is activated by thrombin to factor XIIIa. Factor XIIIa is an enzyme of the blood coagulation system that crosslinks fibrin. Deficiency of XIII worsens clot stability and increases bleeding tendency.
| coagulation factor XIII, A1 polypeptide | |||||||
|---|---|---|---|---|---|---|---|
Inactive A1 peptide homodimer with all of the domains and main catalytic residues shown with different colors. | |||||||
| Identifiers | |||||||
| Symbol | F13A1 | ||||||
| Alt. symbols | F13A | ||||||
| NCBI gene | 2162 | ||||||
| HGNC | 3531 | ||||||
| OMIM | 134570 | ||||||
| RefSeq | NM_000129 | ||||||
| UniProt | P00488 | ||||||
| Other data | |||||||
| EC number | 2.3.2.13 | ||||||
| Locus | Chr. 6 p24.2-p23 | ||||||
| |||||||
| coagulation factor XIII, B polypeptide | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | F13B | ||||||
| NCBI gene | 2165 | ||||||
| HGNC | 3534 | ||||||
| OMIM | 134580 | ||||||
| RefSeq | NM_001994 | ||||||
| UniProt | P05160 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q31-q32.1 | ||||||
| |||||||
Human XIII is a heterotetramer. It consists of 2 enzymatic A peptides and 2 non-enzymatic B peptides. XIIIa is a dimer of activated A peptides.
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