FTH1

FTH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FHA, 2CEI, 2CHI, 2CIH, 2CLU, 2CN6, 2CN7, 2FHA, 2IU2, 2Z6M, 3AJO, 3AJP, 3AJQ, 3ERZ, 3ES3, 4DYX, 4DYY, 4DYZ, 4DZ0, 4OYN, 4Y08, 4YKH, 4ZJK, 5CMQ, 5CMR
Identifiers
Aliases	FTH1, FHC, FTH, FTHL6, HFE5, PIG15, PLIF, ferritin, heavy polypeptide 1, ferritin heavy chain 1
External IDs	OMIM: 134770 MGI: 95588 HomoloGene: 74295 GeneCards: FTH1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	61,967,634 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	9,962,462 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; upper lobe of left lung; ; tibial nerve; ; right lung; ; gastric mucosa; ; left coronary artery; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; monocyte; ; ascending aorta;
	Top expressed in
	globus pallidus; ; pontine nuclei; ; lateral geniculate nucleus; ; lateral hypothalamus; ; duodenum; ; calvaria; ; kidney; ; nucleus accumbens; ; blood; ; dorsal tegmental nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ferric iron binding; metal ion binding; ferroxidase activity; protein binding; oxidoreductase activity; iron ion binding; ferrous iron binding; identical protein binding;
Cellular component	cytosol; intracellular ferritin complex; extracellular exosome; nucleus; extracellular region; autolysosome; tertiary granule lumen; ficolin-1-rich granule lumen; cytoplasm;
Biological process	intracellular sequestering of iron ion; iron ion transport; immune response; negative regulation of fibroblast proliferation; negative regulation of cell population proliferation; cellular iron ion homeostasis; neutrophil degranulation; negative regulation of necrotic cell death;
	Sources:Amigo / QuickGO
Orthologs
	2495
	14319
	ENSG00000167996
	ENSMUSG00000024661
	P02794
	P09528
	NM_002032
	NM_010239
	NP_002023
	NP_034369
	Wikidata
View/Edit Human	View/Edit Mouse

Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene. FTH1 gene is located on chromosome 11, and its mutation causes Hemochromatosis type 5.

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