Forkhead box protein O1

FOXO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CO6, 3CO7, 3COA, 4LG0
Identifiers
Aliases	FOXO1, FKH1, FKHR, FOXO1A, forkhead box O1
External IDs	OMIM: 136533 MGI: 1890077 HomoloGene: 1527 GeneCards: FOXO1
Gene location (Human)
Chr.	Chromosome 13 (human)
End	40,666,641 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	52,260,642 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; synovial membrane; ; pericardium; ; middle frontal gyrus; ; Achilles tendon; ; myometrium; ; sural nerve; ; gastrocnemius muscle; ; superficial temporal artery; ; lower lobe of lung;
	Top expressed in
	secondary oocyte; ; molar; ; aortic valve; ; ascending aorta; ; lymph node; ; Paneth cell; ; cumulus cell; ; submandibular gland; ; condyle; ; fossa;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; beta-catenin binding; DNA-binding transcription factor activity; transcription factor binding; chromatin binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; protein phosphatase 2A binding; ubiquitin protein ligase binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription coactivator binding;
Cellular component	cytoplasm; cytosol; nucleoplasm; mitochondrion; nucleus;
Biological process	insulin receptor signaling pathway; negative regulation of fat cell differentiation; regulation of transcription, DNA-templated; positive regulation of protein catabolic process; glucose homeostasis; positive regulation of autophagy; cellular glucose homeostasis; cellular response to hyperoxia; regulation of transcription by RNA polymerase II; cellular response to starvation; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; regulation of reactive oxygen species metabolic process; transcription, DNA-templated; regulation of neural precursor cell proliferation; cellular response to dexamethasone stimulus; cellular response to DNA damage stimulus; neuronal stem cell population maintenance; autophagy; positive regulation of transcription, DNA-templated; response to insulin; blood vessel development; cellular response to cold; response to fluoride; regulation of cell population proliferation; cellular response to insulin stimulus; positive regulation of apoptotic process; negative regulation of stress-activated MAPK cascade; cellular response to oxidative stress; enamel mineralization; cellular response to nitric oxide; positive regulation of gluconeogenesis; temperature homeostasis; negative regulation of transcription, DNA-templated; fat cell differentiation; negative regulation of canonical Wnt signaling pathway; endocrine pancreas development; protein acetylation; positive regulation of transcription by RNA polymerase II; cellular response to hydrogen peroxide; apoptotic process; anatomical structure morphogenesis; cell differentiation; negative regulation of cardiac muscle hypertrophy in response to stress; cytokine-mediated signaling pathway; energy homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	2308
	56458
	ENSG00000150907
	ENSMUSG00000044167
	Q12778
	Q9R1E0
	NM_002015
	NM_019739
	NP_002006
	NP_062713
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene. FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling, and is also central to the decision for a preadipocyte to commit to adipogenesis. It is primarily regulated through phosphorylation on multiple residues; its transcriptional activity is dependent on its phosphorylation state.

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