FOLR2

FOLR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KMY, 4KMZ, 4KN0, 4KN1, 4KN2
Identifiers
Aliases	FOLR2, BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3, folate receptor beta, FRbeta, FOLR1
External IDs	OMIM: 136425 MGI: 95569 HomoloGene: 627 GeneCards: FOLR2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	72,221,950 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	101,506,401 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; right coronary artery; ; synovial joint; ; lymph node; ; synovial membrane; ; pericardium; ; rectum; ; gastric mucosa; ; smooth muscle tissue; ; subcutaneous adipose tissue;
	Top expressed in
	lip; ; ankle joint; ; white adipose tissue; ; esophagus; ; ankle; ; mammary gland; ; subcutaneous adipose tissue; ; sternocleidomastoid muscle; ; morula; ; ascending aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methotrexate binding; folic acid binding; folic acid receptor activity; signaling receptor activity;
Cellular component	cell surface; anchored component of membrane; anchored component of external side of plasma membrane; membrane; extracellular region; plasma membrane;
Biological process	inflammatory response; receptor-mediated endocytosis; positive regulation of cell population proliferation; monocyte chemotaxis; cellular response to folic acid; folic acid metabolic process; folic acid transport; folate import across plasma membrane; cell adhesion; fusion of sperm to egg plasma membrane involved in single fertilization; sperm-egg recognition;
	Sources:Amigo / QuickGO
Orthologs
	2350
	14276
	ENSG00000165457
	ENSMUSG00000032725
	P14207
	Q05685
	NM_000803; NM_001113534; NM_001113535; NM_001113536
	NM_008035; NM_001303231; NM_001303239
	NP_000794; NP_001107006; NP_001107007; NP_001107008
	NP_001290160; NP_001290168; NP_032061
	Wikidata
View/Edit Human	View/Edit Mouse

Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.

The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.

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