FMS-like tyrosine kinase 3 ligand

FLT3LG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ETE, 3QS7, 3QS9
Identifiers
Aliases	FLT3LG, FL, FLT3L, fms related tyrosine kinase 3 ligand, FLG3L, fms related receptor tyrosine kinase 3 ligand
External IDs	OMIM: 600007 MGI: 95560 HomoloGene: 48021 GeneCards: FLT3LG
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,486,231 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,136,432 bp
RNA expression pattern
	Top expressed in
	blood; ; lymph node; ; canal of the cervix; ; appendix; ; gastric mucosa; ; vagina; ; subcutaneous adipose tissue; ; spleen; ; right coronary artery; ; tibial nerve;
	Top expressed in
	bone marrow; ; spleen; ; islet of Langerhans; ; thymus; ; urinary bladder; ; lip; ; esophagus; ; jejunum; ; duodenum; ; colon;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cytokine activity; protein homodimerization activity; receptor tyrosine kinase binding; signaling receptor binding; 1-phosphatidylinositol-3-kinase activity;
Cellular component	integral component of membrane; membrane; intrinsic component of external side of plasma membrane; plasma membrane; cell surface; extracellular region; extracellular space; intracellular anatomical structure;
Biological process	positive regulation of protein phosphorylation; positive regulation of natural killer cell differentiation; lymphocyte differentiation; positive regulation of cell proliferation in bone marrow; negative regulation of apoptotic process in bone marrow cell; positive regulation of myoblast fusion; positive regulation of cell cycle; positive regulation of myoblast differentiation; positive regulation of cell population proliferation; embryonic hemopoiesis; homeostasis of number of cells within a tissue; regulation of myeloid dendritic cell activation; signal transduction; positive regulation of transcription by RNA polymerase II; positive regulation of osteoclast proliferation; regulation of signaling receptor activity; cytokine-mediated signaling pathway; positive regulation of natural killer cell proliferation; MAPK cascade; phosphatidylinositol-3-phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2323
	14256
	ENSG00000090554
	ENSMUSG00000110206
	P49771
	P49772
	NM_001204502; NM_001204503; NM_001278637; NM_001278638; NM_001459
	NM_013520
NP_001191431; NP_001191432; NP_001265566; NP_001265567; NP_001450;
	NP_001191431.1
NP_038548; NP_001389760; NP_001389761; NP_001389762; NP_001389763;
	NP_001389764; NP_001389765; NP_001389766
	Wikidata
View/Edit Human	View/Edit Mouse

Fms-related tyrosine kinase 3 ligand (FLT3LG) is a protein which in humans is encoded by the FLT3LG gene.

Flt3 ligand (FL) is a hematopoietic four helical bundle cytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating factor 1 (CSF-1). In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors. For example, it is a major growth factor stimulating the growth of dendritic cells.

FLT3L functions as a cytokine and growth factor that increases the number of immune cells (lymphocytes (B cells and T cells)) by activating the hematopoietic progenitors. It acts by binding to and activating FLT3 (CD135) which is found on what (in mice) are called multipotent progenitor (MPP) and common lymphoid progenitor (CLP) cells. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells.

FLT3L is crucial for steady-state plasmacytoid dendritic cell (pDC) and classical dendritic cell (cDC) development. A lack of FLT3L results in low levels of dendritic cells.

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