Fibroblast activation protein, alpha

FAP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z68
Identifiers
Aliases	FAP, DPPIV, FAPA, SIMP, fibroblast activation protein alpha, FAPalpha
External IDs	OMIM: 600403 MGI: 109608 HomoloGene: 48282 GeneCards: FAP
EC number	3.4.14.5
Gene location (Human)
Chr.	Chromosome 2 (human)
End	162,245,151 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	62,404,419 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; islet of Langerhans; ; smooth muscle tissue; ; gallbladder; ; myometrium; ; right coronary artery; ; ascending aorta; ; canal of the cervix; ; left coronary artery; ; visceral pleura;
	Top expressed in
	body of femur; ; retinal pigment epithelium; ; internal carotid artery; ; external carotid artery; ; squamous epithelium; ; mesothelium; ; ankle; ; calvaria; ; intercostal muscle; ; nose;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein dimerization activity; protein homodimerization activity; endopeptidase activity; protease binding; integrin binding; peptidase activity; protein binding; serine-type peptidase activity; metalloendopeptidase activity; serine-type endopeptidase activity; hydrolase activity; dipeptidyl-peptidase activity;
Cellular component	cytoplasm; integral component of membrane; cell projection; membrane; focal adhesion; basal part of cell; plasma membrane; apical part of cell; ruffle membrane; extracellular region; cell surface; cell junction; lamellipodium membrane; lamellipodium; extracellular space;
Biological process	positive regulation of execution phase of apoptosis; regulation of collagen catabolic process; melanocyte apoptotic process; negative regulation of extracellular matrix disassembly; negative regulation of extracellular matrix organization; proteolysis; cell adhesion; negative regulation of cell proliferation involved in contact inhibition; angiogenesis; melanocyte proliferation; proteolysis involved in cellular protein catabolic process; regulation of fibrinolysis; endothelial cell migration; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	2191
	14089
	ENSG00000078098
	ENSMUSG00000000392
	Q12884
	P97321
	NM_001291807; NM_004460
	NM_007986
	NP_001278736; NP_004451
	NP_032012
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast activation protein alpha (FAP-alpha) also known as prolyl endopeptidase FAP is an enzyme that in humans is encoded by the FAP gene.

Prolyl endopeptidase FAP is a 170 kDa membrane-bound gelatinase. It was independently identified as a surface glycoprotein recognized by the F19 monoclonal antibody in activated fibroblasts and a Surface Expressed Protease (seprase) in invasive melanoma cells.

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