Estromustine

Estromustine
Clinical data
Other names	EoM; Leo 271 f; Estrone 17β-3-N-bis(2-chloroethyl)carbamate; Estrone–cytostatic complex
Drug class	Chemotherapeutic agent; Estrogen; Estrogen ester
Pharmacokinetic data
Elimination half-life	14 hours
Identifiers
	IUPAC name [(8R,9S,13S,14S)-13-Methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate;
CAS Number	62899-40-5;
PubChem CID	124946;
ChemSpider	111241;
CompTox Dashboard (EPA)	DTXSID40978673 ;
Chemical and physical data
Formula	C23H29Cl2NO3
Molar mass	438.39 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl;
	InChI InChI=1S/C23H29Cl2NO3/c1-23-9-8-18-17-5-3-16(29-22(28)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)27/h3,5,14,18-20H,2,4,6-13H2,1H3/t18-,19-,20+,23+/m1/s1; Key:AXWYROHIFVWHMR-UGTOYMOASA-N;

Estromustine (developmental code name Leo 271 f), also known as estrone 17β-3-N-bis(2-chloroethyl)carbamate or estrone–cytostatic complex, is a major active metabolite of the cytostatic antineoplastic agent and estrogen estramustine phosphate, a medication used in the treatment of prostate cancer.

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