Estrogen-related receptor gamma

ESRRG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KV6, 1TFC, 1VJB, 2E2R, 2EWP, 2GP7, 2GPO, 2GPP, 2GPU, 2GPV, 2P7A, 2P7G, 2P7Z, 2ZAS, 2ZBS, 2ZKC
Identifiers
Aliases	ESRRG, ERR3, ERRgamma, NR3B3, estrogen related receptor gamma, ERRg, ERR-gamma
External IDs	OMIM: 602969 MGI: 1347056 HomoloGene: 55581 GeneCards: ESRRG
Gene location (Human)
Chr.	Chromosome 1 (human)
End	217,137,755 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	187,947,082 bp
RNA expression pattern
	Top expressed in
	pons; ; kidney tubule; ; endothelial cell; ; renal medulla; ; Brodmann area 23; ; right ventricle; ; parotid gland; ; thoracic diaphragm; ; biceps brachii; ; myocardium;
	Top expressed in
	pontine nuclei; ; medial vestibular nucleus; ; epithelium of stomach; ; lateral geniculate nucleus; ; submandibular gland; ; pineal gland; ; globus pallidus; ; dorsal tegmental nucleus; ; facial motor nucleus; ; myocardium of ventricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; zinc ion binding; AF-2 domain binding; metal ion binding; steroid hormone receptor activity; steroid binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear receptor activity;
Cellular component	nucleoplasm; nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription, DNA-templated; retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; steroid hormone mediated signaling pathway; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	2104
	26381
	ENSG00000196482
	ENSMUSG00000026610
	P62508
	P62509
NM_001134285; NM_001243505; NM_001243506; NM_001243507; NM_001243509;
	NM_001243510; NM_001243511; NM_001243512; NM_001243513; NM_001243514; NM_001243515; NM_001243518; NM_001243519; NM_001438; NM_206594; NM_206595; NM_001350122; NM_001350123; NM_001350124; NM_001350125
	NM_001243792; NM_011935; NM_001357534; NM_001357535; NM_001357536
NP_001127757; NP_001230434; NP_001230435; NP_001230436; NP_001230438;
	NP_001230439; NP_001230440; NP_001230441; NP_001230442; NP_001230443; NP_001230444; NP_001230447; NP_001230448; NP_001429; NP_996317; NP_996318; NP_001337051; NP_001337052; NP_001337053; NP_001337054
	NP_001230721; NP_036065; NP_001344463; NP_001344464; NP_001344465
	Wikidata
View/Edit Human	View/Edit Mouse

Estrogen-related receptor gamma (ERR-gamma), also known as NR3B3 (nuclear receptor subfamily 3, group B, member 3), is a nuclear receptor that in humans is encoded by the ESRRG (EStrogen Related Receptor Gamma) gene. It behaves as a constitutive activator of transcription.

This protein is a member of nuclear hormone receptor family of steroid hormone receptors. No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG. It also seems to be the target of bisphenol A (see below).

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