Erythema multiforme major
In dermatology, erythema multiforme major is a form of rash with skin loss or epidermal detachment.
| Erythema multiforme major | |
|---|---|
| Other names | Erythema multiforme majus |
| Micrograph of confluent epidermal necrosis. H&E stain. | |
| Specialty | Dermatology |
The term "erythema multiforme majus" is sometimes used to imply a bullous (blistering) presentation.
According to some sources, there are two conditions included on a spectrum of this same disease process:
- Stevens–Johnson syndrome (SJS)
- Toxic epidermal necrolysis (TEN) which described by Alan Lyell and previously called Lyell syndrome[5].
In this view, EM major, SJS and TEN are considered a single condition, distinguished by degree of epidermal detachment.
However, a consensus classification separates erythema multiforme minor, erythema multiforme major, and SJS/TEN as three separate entities.
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