Elabela

APELA
Identifiers
Aliases	APELA, ELA, Ende, tdl, apelin receptor early endogenous ligand
External IDs	OMIM: 615594 GeneCards: APELA
Gene location (Human)
Chr.	Chromosome 4 (human)
End	164,898,965 bp
RNA expression pattern
	Top expressed in
	tibia; ; palpebral conjunctiva; ; prostate; ; skin of abdomen; ; placenta; ; Achilles tendon; ; sural nerve; ; kidney; ; bronchial epithelial cell; ; smooth muscle tissue;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	hormone activity; apelin receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	multicellular organism development; mesendoderm migration; cell migration involved in mesendoderm migration; endoderm development; gastrulation; heart development; SMAD protein signal transduction; positive regulation of angiogenesis; apelin receptor signaling pathway; positive regulation of G protein-coupled receptor internalization; regulation of signaling receptor activity; vasculogenesis; mesoderm migration involved in gastrulation; adult heart development; embryonic heart tube development; positive regulation of heart contraction; placenta blood vessel development; coronary vasculature development; positive regulation of ERK1 and ERK2 cascade; positive regulation of trophoblast cell migration; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; angiogenesis; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	100506013
	n/a
	ENSG00000248329
	n/a
	P0DMC3
	n/a
	NM_001297550
	n/a
	NP_001284479
	n/a
	Wikidata
View/Edit Human

ELABELA (ELA, Apela, Toddler) is a hormonal peptide that in humans is encoded by the APELA gene. Elabela is one of two endogenous ligands for the G-protein-coupled APLNR receptor.

Ela is secreted by certain cell types including human embryonic stem cells. It is widely expressed in various developing organs such as the blastocyst, placenta, heart, kidney, endothelium, and is circulating in human plasma.

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