ERM protein family
The ERM protein family consists of three closely related proteins, ezrin, radixin and moesin. The three paralogs, ezrin, radixin and moesin, are present in vertebrates, whereas other species have only one ERM gene. Therefore, in vertebrates these paralogs likely arose by gene duplication.
| Ezrin/radixin/moesin family | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Crystallographic structure of the N-terminal domain of moesin. | |||||||||||
| Identifiers | |||||||||||
| Symbol | ERM | ||||||||||
| Pfam | PF00769 | ||||||||||
| InterPro | IPR011259 | ||||||||||
| SCOP2 | 1ef1 / SCOPe / SUPFAM | ||||||||||
| |||||||||||
ERM proteins are highly conserved throughout evolution. More than 75% identity is observed in the N-terminal and the C-terminal of vertebrates (ezrin, radixin, moesin), Drosophila (dmoesin) and C. elegans (ERM-1) homologs.
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