ERCC6

ERCC6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CVO
Identifiers
Aliases	ERCC6, ARMD5, CKN2, COFS, COFS1, CSB, RAD26, UVSS1, POF11, ERCC excision repair 6, chromatin remodeling factor, excision repair cross-complementing group 6
External IDs	OMIM: 609413 MGI: 1100494 HomoloGene: 133552 GeneCards: ERCC6
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	32,302,947 bp
Gene ontology
Molecular function	nucleotide binding; ATP-dependent activity, acting on DNA; protein tyrosine kinase activator activity; helicase activity; protein N-terminus binding; chromatin binding; DNA helicase activity; protein C-terminus binding; protein binding; hydrolase activity; DNA binding; ATP binding; RNA polymerase binding; protein-containing complex binding; sequence-specific DNA binding;
Cellular component	nucleoplasm; nucleolus; transcription elongation factor complex; nucleus; nuclear body;
Biological process	pyrimidine dimer repair; epigenetic maintenance of chromatin in transcription-competent conformation; response to superoxide; regulation of transcription, DNA-templated; multicellular organism growth; regulation of DNA-templated transcription, elongation; transcription by RNA polymerase II; transcription, DNA-templated; cellular response to DNA damage stimulus; positive regulation of DNA-templated transcription, elongation; transcription elongation from RNA polymerase I promoter; intrinsic apoptotic signaling pathway in response to DNA damage; response to UV-B; photoreceptor cell maintenance; response to gamma radiation; response to toxic substance; response to X-ray; base-excision repair; response to oxidative stress; positive regulation of protein tyrosine kinase activity; response to UV; transcription-coupled nucleotide-excision repair; DNA repair; DNA duplex unwinding; positive regulation of DNA repair;
	Sources:Amigo / QuickGO
Orthologs
	2074
	319955
	ENSG00000225830
	ENSMUSG00000054051
	P0DP91; Q8N328
	F8VPZ5
	n/a
	NM_001081221
	NP_000115; NP_001263987; NP_001263988; NP_001333369; NP_736609
	NP_001074690
	Wikidata
View/Edit Human	View/Edit Mouse

DNA excision repair protein ERCC-6 (also CS-B protein) is a protein that in humans is encoded by the ERCC6 gene. The ERCC6 gene is located on the long arm of chromosome 10 at position 11.23.

Having 1 or more copies of a mutated ERCC6 causes Cockayne syndrome, type II.

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