EIF4G3

EIF4G3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HU3
Identifiers
Aliases	EIF4G3, eIF-4G 3, eIF4G 3, eIF4GII, eukaryotic translation initiation factor 4 gamma 3
External IDs	OMIM: 603929 MGI: 1923935 HomoloGene: 2789 GeneCards: EIF4G3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	21,177,285 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	138,208,508 bp
RNA expression pattern
	Top expressed in
	sperm; ; frontal pole; ; Brodmann area 10; ; middle frontal gyrus; ; stromal cell of endometrium; ; postcentral gyrus; ; ganglionic eminence; ; Brodmann area 23; ; superior frontal gyrus; ; entorhinal cortex;
	Top expressed in
	seminiferous tubule; ; knee joint; ; cerebellar cortex; ; superior frontal gyrus; ; triceps brachii muscle; ; temporal muscle; ; digastric muscle; ; prefrontal cortex; ; sternocleidomastoid muscle; ; medullary collecting duct;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA cap binding; translation factor activity, RNA binding; translation initiation factor activity; RNA binding; protein binding; mRNA binding;
Cellular component	cytosol; eukaryotic translation initiation factor 4F complex;
Biological process	translational initiation; viral process; protein biosynthesis; regulation of translation; regulation of translational initiation; negative regulation of autophagy;
	Sources:Amigo / QuickGO
Orthologs
	8672
	230861
	ENSG00000075151
	ENSMUSG00000028760
	O43432
	Q80XI3
NM_001198801; NM_001198802; NM_001198803; NM_003760; NM_001391892;
	NM_001391893; NM_001391894; NM_001391895; NM_001391896; NM_001391897; NM_001391898; NM_001391899; NM_001391900; NM_001391901; NM_001391902; NM_001391903; NM_001391904; NM_001391905; NM_001391906; NM_001391907
	NM_001256195; NM_001256198; NM_172703; NM_001355699; NM_001355700
	NP_001185730; NP_001185731; NP_001185732; NP_003751
NP_001243124; NP_001243127; NP_766291; NP_001342628; NP_001342629;
	NP_001356059; NP_001356060
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene. The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template. Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.

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