EIF4A1

EIF4A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2G9N, 2ZU6, 3EIQ
Identifiers
Aliases	EIF4A1, DDX2A, EIF-4A, EIF4A, eIF-4A-I, eIF4A-I, eukaryotic translation initiation factor 4A1
External IDs	OMIM: 602641 MGI: 95303 HomoloGene: 103998 GeneCards: EIF4A1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,579,006 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,563,249 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; left uterine tube; ; stromal cell of endometrium; ; islet of Langerhans; ; skin of abdomen; ; upper lobe of left lung; ; bone marrow; ; appendix; ; cervix; ; bone marrow cells;
	Top expressed in
	ganglionic eminence; ; lens; ; ovary; ; thymus; ; mesencephalon; ; uterus; ; yolk sac; ; neural tube; ; placenta; ; zone of skin;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; helicase activity; translation initiation factor activity; translation factor activity, RNA binding; protein binding; nucleic acid binding; RNA cap binding; double-stranded RNA binding; hydrolase activity; ATP binding; mRNA binding; RNA binding;
Cellular component	cytoplasm; cytosol; membrane; eukaryotic translation initiation factor 4F complex; extracellular exosome; nucleus; extracellular matrix;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; RNA secondary structure unwinding; translational initiation; regulation of gene expression; viral process; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	1973
	13681
	ENSG00000161960
	ENSMUSG00000059796
	P60842
	P60843
	NM_001416; NM_001204510
	NM_001159375; NM_144958
	NP_001191439; NP_001407
	NP_001152847; NP_659207
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic initiation factor 4A-I (also known as eIF4A1 or DDX2A) is a 46 kDa cytosolic protein that, in humans, is encoded by the EIF4A1 gene, which is located on chromosome 17. It is the most prevalent member of the eIF4A family of ATP-dependant RNA helicases, and plays a critical role in the initiation of cap-dependent eukaryotic protein translation as a component of the eIF4F translation initiation complex. eIF4A1 unwinds the secondary structure of RNA within the 5'-UTR of mRNA, a critical step necessary for the recruitment of the 43S preinitiation complex, and thus the translation of protein in eukaryotes. It was first characterized in 1982 by Grifo, et al., who purified it from rabbit reticulocyte lysate.

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