EIF2AK4

EIF2AK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UKX, 4OTN
Identifiers
Aliases	EIF2AK4, GCN2, PVOD2, eukaryotic translation initiation factor 2 alpha kinase 4
External IDs	OMIM: 609280 MGI: 1353427 HomoloGene: 40891 GeneCards: EIF2AK4
Gene location (Human)
Chr.	Chromosome 15 (human)
End	40,035,591 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	118,305,715 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; bone marrow cells; ; stromal cell of endometrium; ; synovial membrane; ; tibia; ; Achilles tendon; ; Brodmann area 9; ; nucleus accumbens; ; left uterine tube; ; caudate nucleus;
	Top expressed in
	medullary collecting duct; ; secondary oocyte; ; saccule; ; otic placode; ; Paneth cell; ; external carotid artery; ; internal carotid artery; ; fossa; ; vas deferens; ; substantia nigra;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; tRNA binding; kinase activity; protein serine/threonine kinase activity; RNA binding; ATP binding; eukaryotic translation initiation factor 2alpha kinase activity;
Cellular component	cytoplasm; polysome; cytosolic ribosome;
Biological process	positive regulation of translational initiation in response to starvation; adaptive immune response; negative regulation of neuron differentiation; positive regulation of long-term synaptic potentiation; positive regulation of adaptive immune response; negative regulation of translational initiation in response to stress; negative regulation of translational initiation; phosphorylation; immune system process; cellular response to UV; cellular response to amino acid starvation; negative regulation of CREB transcription factor activity; regulation of feeding behavior; learning; nervous system development; viral translation; neuron projection extension; protein phosphorylation; cellular response to cold; long-term memory; defense response to virus; cellular response to leucine starvation; eiF2alpha phosphorylation in response to endoplasmic reticulum stress; induction by virus of host autophagy; protein autophosphorylation; cell cycle; negative regulation by host of viral genome replication; viral process; regulation of translation; regulation of translational initiation; positive regulation of defense response to virus by host; T cell activation involved in immune response; DNA damage checkpoint signaling; regulation of translational initiation by eIF2 alpha phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	440275
	27103
	ENSG00000128829
	ENSMUSG00000005102
	Q9P2K8
	Q9QZ05
	NM_001013703
	NM_001177806; NM_013719; NM_001355383
	NP_001013725
	NP_001171277; NP_038747; NP_001342312
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene.

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999).[supplied by OMIM]

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.