EIF2AK1

EIF2AK1
Identifiers
Aliases	EIF2AK1, HCR, HRI, eukaryotic translation initiation factor 2 alpha kinase 1, LEMSPAD, hHRI
External IDs	OMIM: 613635 MGI: 1353448 HomoloGene: 8290 GeneCards: EIF2AK1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	6,059,175 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	143,841,069 bp
RNA expression pattern
	Top expressed in
	spongy bone; ; monocyte; ; parotid gland; ; islet of Langerhans; ; bone marrow; ; bone marrow cells; ; stromal cell of endometrium; ; rectum; ; ganglionic eminence; ; placenta;
	Top expressed in
	secondary oocyte; ; maxillary prominence; ; bone marrow; ; epithelium of stomach; ; spleen; ; blood; ; internal carotid artery; ; triceps brachii muscle; ; atrium; ; proximal tubule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein serine/threonine kinase activity; ATP binding; heme binding; protein homodimerization activity; eukaryotic translation initiation factor 2alpha kinase activity; translation initiation factor activity;
Cellular component	cytoplasm;
Biological process	negative regulation of translation; phosphorylation; regulation of hemoglobin biosynthetic process; iron ion homeostasis; macrophage differentiation; protein phosphorylation; regulation of translational initiation by eIF2 alpha phosphorylation; acute inflammatory response; protoporphyrinogen IX metabolic process; regulation of eIF2 alpha phosphorylation by heme; phagocytosis; negative regulation of translational initiation by iron; regulation of translation; negative regulation of cell population proliferation; protein autophosphorylation; negative regulation of hemoglobin biosynthetic process; response to iron ion starvation; translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	27102
	15467
	ENSG00000086232
	ENSMUSG00000029613
	Q9BQI3
	Q9Z2R9
	NM_014413; NM_001134335
	NM_013557
	NP_001127807; NP_055228; NP_055228.2
	NP_038585
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 2-alpha kinase 1 is an enzyme that in humans is encoded by the EIF2AK1 gene.

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