E-selectin

SELE
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ESL, 1G1T, 4C16, 4CSY
Identifiers
Aliases	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2, selectin E, selectin-e
External IDs	OMIM: 131210 MGI: 98278 HomoloGene: 389 GeneCards: SELE
Gene location (Human)
Chr.	Chromosome 1 (human)
End	169,764,705 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	163,885,246 bp
RNA expression pattern
	Top expressed in
	vena cava; ; left uterine tube; ; seminal vesicula; ; trachea; ; gastric mucosa; ; mucosa of urinary bladder; ; gallbladder; ; saphenous vein; ; right lobe of thyroid gland; ; left lobe of thyroid gland;
	Top expressed in
	spermatid; ; spermatocyte; ; intestinal villus; ; semi-lunar valve; ; atrioventricular valve; ; lip; ; aortic valve; ; adrenal gland; ; dentate gyrus; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phospholipase binding; oligosaccharide binding; protein binding; transmembrane signaling receptor activity; carbohydrate binding; sialic acid binding; metal ion binding;
Cellular component	integral component of membrane; membrane; cortical cytoskeleton; plasma membrane; perinuclear region of cytoplasm; caveola; membrane raft; clathrin-coated pit; extracellular space; integral component of plasma membrane;
Biological process	leukocyte cell-cell adhesion; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; response to interleukin-1; positive regulation of receptor internalization; actin filament-based process; leukocyte migration involved in inflammatory response; activation of phospholipase C activity; response to tumor necrosis factor; response to lipopolysaccharide; cell adhesion; regulation of inflammatory response; leukocyte tethering or rolling; inflammatory response; leukocyte migration; calcium-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	6401
	20339
	ENSG00000007908
	ENSMUSG00000026582
	P16581
	Q00690
	NM_000450
	NM_011345
	NP_000441
	NP_035475
	Wikidata
View/Edit Human	View/Edit Mouse

E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation. In humans, E-selectin is encoded by the SELE gene.

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