Dystroglycan

DAG1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EG4, 2MK7
Identifiers
Aliases	DAG1, 156DAG, A3a, AGRNR, DAG, MDDGC7, MDDGC9, MDDGA9, dystroglycan 1, LGMDR16
External IDs	OMIM: 128239 MGI: 101864 HomoloGene: 3234 GeneCards: DAG1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	49,535,618 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	108,141,157 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; trigeminal ganglion; ; spinal ganglia; ; glomerulus; ; metanephric glomerulus; ; pancreatic ductal cell; ; placenta; ; parotid gland; ; nipple; ; saphenous vein;
	Top expressed in
	sciatic nerve; ; renal corpuscle; ; left lung; ; left lung lobe; ; myocardium of ventricle; ; right ventricle; ; right lung; ; cardiac muscles; ; triceps brachii muscle; ; Paneth cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; virus receptor activity; alpha-actinin binding; vinculin binding; actin binding; tubulin binding; structural constituent of muscle; SH2 domain binding; laminin binding; laminin-1 binding; dystroglycan binding;
Cellular component	cell-cell junction; nucleus; synapse; contractile ring; filopodium; node of Ranvier; costamere; lamellipodium; dystroglycan complex; membrane raft; cell junction; cytoskeleton; membrane; extracellular exosome; basolateral plasma membrane; postsynaptic membrane; sarcolemma; cytoplasm; integral component of membrane; focal adhesion; plasma membrane; dystrophin-associated glycoprotein complex; nucleoplasm; basement membrane; cytosol; extracellular space; endoplasmic reticulum lumen; Golgi lumen; plasma membrane raft; external side of plasma membrane; nuclear periphery; extracellular matrix; extracellular region; collagen-containing extracellular matrix; glutamatergic synapse; GABA-ergic synapse; postsynaptic cytosol;
Biological process	NLS-bearing protein import into nucleus; extracellular matrix organization; viral process; regulation of embryonic cell shape; response to peptide hormone; regulation of epithelial to mesenchymal transition; positive regulation of basement membrane assembly involved in embryonic body morphogenesis; viral entry into host cell; regulation of gastrulation; negative regulation of cell migration; Schwann cell development; membrane protein ectodomain proteolysis; calcium-dependent cell-matrix adhesion; negative regulation of MAPK cascade; nerve maturation; microtubule anchoring; commissural neuron axon guidance; branching involved in salivary gland morphogenesis; negative regulation of protein kinase B signaling; morphogenesis of an epithelial sheet; myelination in peripheral nervous system; basement membrane organization; epithelial tube branching involved in lung morphogenesis; modulation by virus of host process; protein O-linked glycosylation; positive regulation of cell-matrix adhesion; human ageing; Schwann cell differentiation; response to denervation involved in regulation of muscle adaptation; nerve development; axon regeneration; positive regulation of myelination; skeletal muscle tissue regeneration; positive regulation of protein kinase activity; positive regulation of oligodendrocyte differentiation; cellular response to mechanical stimulus; cellular response to cholesterol; angiogenesis involved in wound healing; regulation of synapse organization; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; retrograde trans-synaptic signaling by trans-synaptic protein complex;
	Sources:Amigo / QuickGO
Orthologs
	1605
	13138
	ENSG00000173402
	ENSMUSG00000039952
	Q14118
	Q62165
NM_004393; NM_001165928; NM_001177634; NM_001177635; NM_001177636;
	NM_001177637; NM_001177638; NM_001177639; NM_001177640; NM_001177641; NM_001177642; NM_001177643; NM_001177644
NM_001276481; NM_001276482; NM_001276485; NM_001276486; NM_001276492;
	NM_001276493; NM_001276494; NM_010017
NP_001159400; NP_001171105; NP_001171106; NP_001171107; NP_001171108;
	NP_001171109; NP_001171110; NP_001171111; NP_001171112; NP_001171113; NP_001171114; NP_001171115; NP_004384
NP_001263410; NP_001263411; NP_001263414; NP_001263415; NP_001263421;
	NP_001263422; NP_034147
	Wikidata
View/Edit Human	View/Edit Mouse

Dystroglycan is a protein that in humans is encoded by the DAG1 gene.

Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in Homo sapiens on chromosome 3. There are two exons that are separated by a large intron. The spliced exons code for a protein product that is finally cleaved into two non-covalently associated subunits, [alpha] (N-terminal) and [beta] (C-terminal).

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