District X

District X, also known as Mutant Town or the Middle East Side, is a fictional location that appears in American comic books published by Marvel Comics. It is a neighborhood based in New York City primarily populated by mutants, first seen during Grant Morrison's run on the series New X-Men in New X-Men #127. The neighborhood was established in Alphabet City, Manhattan (also known as Loisaida), a neighborhood in the East Village (located between Avenues A to D, and between Houston and 14th Streets). This would fall within New York's 12th congressional district and the New York City Council's 2nd district. According to the front cover of X-Factor #31, it had a population of 743, having been much reduced by the Decimation.

District X also refers to a comic book series about the neighborhood and its inhabitants. Written by David Hine, the series was a police procedural, starring Bishop and Ismael Ortega, who investigated crimes committed by and against the ghetto's mutant residents. The series also explored Ortega's complicated personal relationships and gradual descent into drug abuse and adultery. It ran as District X for 14 monthly issues beginning in May 2004, then as Mutopia X as part of the crossover House of M event for five monthly issues beginning in July 2005.