Diphtheria toxin
Diphtheria toxin is an exotoxin secreted mainly by Corynebacterium diphtheriae but also by Corynebacterium ulcerans and Corynebacterium pseudotuberculosis, the pathogenic bacterium that causes diphtheria. The toxin gene is encoded by a prophage called corynephage β. The toxin causes the disease in humans by gaining entry into the cell cytoplasm and inhibiting protein synthesis.
| tox diphtheria toxin precursor | |||||||
|---|---|---|---|---|---|---|---|
Cartoon representation of the diphtheria toxin protein | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | tox | ||||||
| Entrez | 2650491 | ||||||
| RefSeq (Prot) | NP_938615 | ||||||
| UniProt | P00587 | ||||||
| Other data | |||||||
| EC number | 2.4.2.36 | ||||||
| Chromosome | genome: 0.19 - 0.19 Mb | ||||||
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| Diphtheria toxin, C domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Diphtheria_C | ||||||||
| Pfam | PF02763 | ||||||||
| Pfam clan | CL0084 | ||||||||
| InterPro | IPR022406 | ||||||||
| SCOP2 | 1ddt / SCOPe / SUPFAM | ||||||||
| TCDB | 1.C.7 | ||||||||
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| Diphtheria toxin, T domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Diphtheria_T | ||||||||
| Pfam | PF02764 | ||||||||
| InterPro | IPR022405 | ||||||||
| SCOP2 | 1ddt / SCOPe / SUPFAM | ||||||||
| TCDB | 1.C.7 | ||||||||
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| Diphtheria toxin, R domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Diphtheria_R | ||||||||
| Pfam | PF01324 | ||||||||
| InterPro | IPR022404 | ||||||||
| SCOP2 | 1ddt / SCOPe / SUPFAM | ||||||||
| TCDB | 1.C.7 | ||||||||
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