Dimethylacetamide
Dimethylacetamide (DMAc or DMA) is the organic compound with the formula CH3C(O)N(CH3)2. This colorless, water-miscible, high-boiling liquid is commonly used as a polar solvent in organic synthesis. DMA is miscible with most other solvents, although it is poorly soluble in aliphatic hydrocarbons.
| Names | |
|---|---|
| Preferred IUPAC name
N,N-Dimethylacetamide | |
| Identifiers | |
3D model (JSmol) |
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| Abbreviations | DMA, DMAC, DMAc |
| 1737614 | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.004.389 |
| EC Number |
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| MeSH | dimethylacetamide |
PubChem CID |
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| RTECS number |
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| UNII | |
CompTox Dashboard (EPA) |
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SMILES
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| Properties | |
| C4H9NO | |
| Molar mass | 87.122 g·mol−1 |
| Appearance | Colorless liquid |
| Odor | Ammoniacal |
| Density | 0.937 g/mL |
| Melting point | −20 °C (−4 °F; 253 K) |
| Boiling point | 165.1 °C; 329.1 °F; 438.2 K |
| Miscible | |
| log P | −0.253 |
| Vapor pressure | 300 Pa |
| UV-vis (λmax) | 270 nm |
Refractive index (nD) |
1.4375 |
| Viscosity | 0.945 mPa·s |
| Thermochemistry | |
Heat capacity (C) |
178.2 J/(K·mol) |
Std enthalpy of formation (ΔfH⦵298) |
−300.1 kJ/mol |
Std enthalpy of combustion (ΔcH⦵298) |
−2.5835–−2.5805 MJ/mol |
| Hazards | |
| GHS labelling: | |
| Danger | |
| H312, H319, H332, H360 | |
| P280, P308+P313 | |
| NFPA 704 (fire diamond) |
2
2
0 |
| Flash point | 63 °C (145 °F; 336 K) |
| 490 °C (914 °F; 763 K) | |
| Explosive limits | 1.8–11.5% |
| Lethal dose or concentration (LD, LC): | |
LD50 (median dose) |
2.24 g/kg (dermal, rabbit) 4.3 g/kg (oral, rat) 4.8 g/kg (oral, rat) 4.62 g/kg (oral, mouse) |
LC50 (median concentration) |
2475 ppm (rat, 1 h) |
| NIOSH (US health exposure limits): | |
PEL (Permissible) |
TWA 10 ppm (35 mg/m3) [skin] |
REL (Recommended) |
TWA 10 ppm (35 mg/m3) [skin] |
IDLH (Immediate danger) |
300 ppm |
| Related compounds | |
Related compounds |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references | |
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