Diloxanide

Diloxanide
Clinical data
Trade names	Furamide
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	by mouth
ATC code	P01AC01 (WHO) ;
Pharmacokinetic data
Bioavailability	90% (diloxanide)
Metabolism	Hydrolyzed to furoic acid and diloxanide, which undergoes extensive glucuronidation
Elimination half-life	3 hours
Excretion	Kidney (90%), fecal (10%)
Identifiers
	IUPAC name 4-[(Dichloroacetyl)(methyl)amino]phenyl furan-2-carboxylate;
CAS Number	3736-81-0 ;
PubChem CID	19529;
DrugBank	DB08792 ;
ChemSpider	18400 ;
UNII	YP4N72IW34;
KEGG	D02480 ;
ChEMBL	ChEMBL1334860 ;
CompTox Dashboard (EPA)	DTXSID0022939 ;
ECHA InfoCard	100.008.583
Chemical and physical data
Formula	C14H11Cl2NO4
Molar mass	328.15 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	112.5 to 114 °C (234.5 to 237.2 °F)
	SMILES O=C(Oc1ccc(N(C(=O)C(Cl)Cl)C)cc1)c2occc2;
	InChI InChI=1S/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3 ; Key:BDYYDXJSHYEDGB-UHFFFAOYSA-N ;
	(what is this?) (verify)

Diloxanide is a medication used to treat amoeba infections. In places where infections are not common, it is a second line treatment after paromomycin when a person has no symptoms. For people who are symptomatic, it is used after treatment with metronidazole or tinidazole. It is taken by mouth.

Diloxanide generally has mild side effects. Side effects may include flatulence, vomiting, and itchiness. During pregnancy it is recommended that it be taken after the first trimester. It is a luminal amebicide meaning that it only works on infections within the intestines.

Diloxanide came into medical use in 1956. It is on the World Health Organization's List of Essential Medicines. It is not commercially available in much of the developed world as of 2012.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.