Dezocine

Dezocine
Clinical data
Trade names	Dalgan
Other names	WY-16225
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Intravenous infusion, intramuscular injection
ATC code	N02AX03 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	2.2 hours
Identifiers
	IUPAC name (5R,11S,13R)-13-Amino-5-methyl-5,6,7,8,9,10,11,12-octahydro-5,11-methanobenzo[10]annulen-3-ol;
CAS Number	53648-55-8 ;
PubChem CID	3033053;
DrugBank	DB01209 ;
ChemSpider	2297867 ;
UNII	VHX8K5SV4X;
KEGG	D00838 ;
ChEBI	CHEBI:4474 ;
ChEMBL	ChEMBL1685 ;
CompTox Dashboard (EPA)	DTXSID2022911 ;
Chemical and physical data
Formula	C16H23NO
Molar mass	245.366 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1ccc2c(c1)[C@@]3(C)CCCCC[C@@H](C2)[C@H]3N;
	InChI InChI=1S/C16H23NO/c1-16-8-4-2-3-5-12(15(16)17)9-11-6-7-13(18)10-14(11)16/h6-7,10,12,15,18H,2-5,8-9,17H2,1H3/t12-,15-,16+/m0/s1 ; Key:VTMVHDZWSFQSQP-VBNZEHGJSA-N ;
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Dezocine, sold under the brand name Dalgan, is an atypical opioid analgesic which is used in the treatment of pain. It is used by intravenous infusion and intramuscular injection.

Dezocine is an opioid receptor modulator, acting as a partial agonist of the μ- and κ-opioid receptors. It has a similar profile of effects to related opioids acting at the μ-opioid receptor, including analgesia and euphoria. Unlike other opioids acting at the κ-opioid receptor however, dezocine does not produce side effects such as dysphoria or hallucinations at any therapeutically used dose.

Dezocine was first synthesized in 1970. It was introduced for medical use in the United States in 1986 but was not marketed in other countries. Dezocine was discontinued in the United States in 2011 with no official reason given. However, it has become one of the most widely used analgesics in China. In light of the opioid epidemic, dezocine has seen a resurgence in use and interest.

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