Desipramine

Desipramine
Clinical data
Trade names	Norpramin, Pertofrane, others
Other names	Desmethylimipramine; Norimipramine; EX-4355; G-35020; JB-8181; NSC-114901
AHFS/Drugs.com	Monograph
MedlinePlus	a682387
Routes of; administration	Oral, intramuscular injection
ATC code	N06AA01 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances); US: WARNINGRx-only;
Pharmacokinetic data
Bioavailability	60–70%
Protein binding	91%
Metabolism	Liver (CYP2D6)
Elimination half-life	12–30 hours
Excretion	Urine (70%), feces
Identifiers
	IUPAC name 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine;
CAS Number	50-47-5 ; 58-28-6 (hydrochloride); 62265-06-9 (dibudinate);
PubChem CID	2995;
IUPHAR/BPS	2399;
DrugBank	DB01151 ;
ChemSpider	2888 ;
UNII	TG537D343B;
KEGG	D07791 ;
ChEBI	CHEBI:47781 ;
ChEMBL	ChEMBL72 ;
CompTox Dashboard (EPA)	DTXSID6022896 ;
ECHA InfoCard	100.000.037
Chemical and physical data
Formula	C18H22N2
Molar mass	266.388 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1cc3c(cc1)CCc2c(cccc2)N3CCCNC;
	InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 ; Key:HCYAFALTSJYZDH-UHFFFAOYSA-N ;
	(verify)

Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α₁-blocking, antihistamine, and anticholinergic effects. The drug is not considered a first-line treatment for depression since the introduction of selective serotonin reuptake inhibitor (SSRI) antidepressants, which have fewer side effects and are safer in overdose.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.