Death receptor 3

TNFRSF25
Identifiers
Aliases	TNFRSF25, APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR, tumor necrosis factor receptor superfamily member 25, TNF receptor superfamily member 25, GEF720, PLEKHG5
External IDs	OMIM: 603366 MGI: 1934667 HomoloGene: 13202 GeneCards: TNFRSF25
Gene location (Human)
Chr.	Chromosome 1 (human)
End	6,466,175 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	152,204,576 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; skin of abdomen; ; right uterine tube; ; spleen; ; sural nerve; ; lymph node; ; Brodmann area 9; ; cingulate gyrus; ; nucleus accumbens; ; cerebellar vermis;
	Top expressed in
	morula; ; superior frontal gyrus; ; yolk sac; ; lens; ; lip; ; thymus; ; blood; ; hippocampus proper; ; renal corpuscle; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	tumor necrosis factor-activated receptor activity; signaling receptor activity;
Cellular component	integral component of membrane; extracellular region; cytosol; plasma membrane; integral component of plasma membrane; membrane;
Biological process	regulation of apoptotic process; multicellular organism development; apoptotic signaling pathway; cell surface receptor signaling pathway; response to lipopolysaccharide; inflammatory response; tumor necrosis factor-mediated signaling pathway; regulation of cell population proliferation; immune response; signal transduction; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	8718
	85030
	ENSG00000215788
	ENSMUSG00000024793
	Q93038
	n/a
NM_148974; NM_001039664; NM_003790; NM_148965; NM_148966;
	NM_148967; NM_148968; NM_148969; NM_148970; NM_148971; NM_148972; NM_148973
	NM_001291010; NM_033042
NP_001034753; NP_003781; NP_683866; NP_683867; NP_683868;
	NP_683871
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Death receptor 3 (DR3), also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25), is a cell surface receptor of the tumor necrosis factor receptor superfamily which mediates apoptotic signalling and differentiation. Its only known TNFSF ligand is TNF-like protein 1A (TL1A).

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