Desmoglein-1

DSG1
Identifiers
Aliases	DSG1, CDHF4, DG1, DSG, EPKHE, EPKHIA, PPKS1, SPPK1, desmoglein 1
External IDs	OMIM: 125670 MGI: 2664357 HomoloGene: 1463 GeneCards: DSG1
Gene location (Human)
Chr.	Chromosome 18 (human)
End	31,359,246 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	20,543,253 bp
RNA expression pattern
	Top expressed in
	vulva; ; nipple; ; human penis; ; skin of abdomen; ; hair follicle; ; gums; ; cervix epithelium; ; oral cavity; ; body of tongue; ; epithelium of esophagus;
	Top expressed in
	esophagus; ; lip; ; zone of skin; ; spermatid; ; testicle; ; stomach; ; spermatocyte; ; thymus; ; limb; ; nervous system;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; gamma-catenin binding; metal ion binding; protein binding; toxic substance binding;
Cellular component	integral component of membrane; cytosol; lateral plasma membrane; membrane; cell-cell junction; plasma membrane; desmosome; cell junction; apical plasma membrane; cytoplasmic side of plasma membrane; cornified envelope; ficolin-1-rich granule membrane;
Biological process	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; maternal process involved in female pregnancy; response to progesterone; protein stabilization; cell adhesion; cell-cell junction assembly; homophilic cell adhesion via plasma membrane adhesion molecules; keratinization; neutrophil degranulation; cornification; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1828
	225256
	ENSG00000134760
	ENSMUSG00000061928
	Q02413
	Q7TSF1
	NM_001942
	NM_181682
	NP_001933
	NP_859010
	Wikidata
View/Edit Human	View/Edit Mouse

Desmoglein-1 is a protein that in humans is encoded by the DSG1 gene. Desmoglein-1 is expressed everywhere in the skin epidermis, but mainly it is expressed in the superficial upper layers of the skin epidermis.

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