DPP7

DPP7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JYH, 3N0T, 4EBB
Identifiers
Aliases	DPP7, DPP2, DPPII, QPP, dipeptidyl peptidase 7
External IDs	OMIM: 610537 MGI: 1933213 HomoloGene: 22748 GeneCards: DPP7
Gene location (Human)
Chr.	Chromosome 9 (human)
End	137,115,177 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,246,371 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right uterine tube; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; Brodmann area 9; ; minor salivary glands; ; cingulate gyrus; ; body of stomach; ; right coronary artery; ; skin of abdomen;
	Top expressed in
	yolk sac; ; calvaria; ; proximal tubule; ; kidney; ; iris; ; islet of Langerhans; ; corneal stroma; ; blastocyst; ; morula; ; ciliary body;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; hydrolase activity; aminopeptidase activity; serine-type peptidase activity; dipeptidyl-peptidase activity;
Cellular component	cytosol; Golgi apparatus; lysosome; cytoplasmic vesicle; vesicle; intracellular membrane-bounded organelle; extracellular exosome; extracellular region; azurophil granule lumen;
Biological process	neutrophil degranulation; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	29952
	83768
	ENSG00000176978
	ENSMUSG00000026958
	Q9UHL4
	Q9ET22
	NM_013379
	NM_031843
	NP_037511
	NP_114031
	Wikidata
View/Edit Human	View/Edit Mouse

Dipeptidyl-peptidase 2 is an enzyme that in humans is encoded by the DPP7 gene.

The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolyl carboxypeptidase and is active at both acidic and neutral pH.

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