DPP6

DPP6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XFD
Identifiers
Aliases	DPP6, DPPX, VF2, MRD33, DPL1, dipeptidyl peptidase like 6
External IDs	OMIM: 126141 MGI: 94921 HomoloGene: 22560 GeneCards: DPP6
Gene location (Human)
Chr.	Chromosome 7 (human)
End	154,894,285 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	27,932,503 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; endothelial cell; ; pons; ; superior frontal gyrus; ; postcentral gyrus; ; entorhinal cortex; ; Region I of hippocampus proper; ; internal globus pallidus; ; superior vestibular nucleus;
	Top expressed in
	cerebellar cortex; ; habenula; ; superior frontal gyrus; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; superior colliculus; ; supraoptic nucleus; ; ventral tegmental area; ; lateral geniculate nucleus; ; ventromedial nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	potassium channel regulator activity; serine-type peptidase activity; dipeptidyl-peptidase activity;
Cellular component	integral component of membrane; plasma membrane; membrane; voltage-gated potassium channel complex;
Biological process	protein localization to plasma membrane; regulation of potassium ion transmembrane transport; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	1804
	13483
	ENSG00000130226; ENSG00000282974
	ENSMUSG00000061576
	P42658; Q8IYG9
	Q9Z218
	NM_001039350; NM_001290252; NM_001290253; NM_001936; NM_130797
	NM_001136060; NM_001198886; NM_010075; NM_207282
NP_001034439; NP_001277181; NP_001277182; NP_001927; NP_570629;
	NP_001351426; NP_001351427; NP_001351428; NP_001351429; NP_001351430; NP_001351431; NP_001277182.1; NP_570629.2; NP_001034439.1; NP_001277181.1; NP_001927.3; NP_570629.2
	NP_001129532; NP_001185815; NP_034205; NP_997165
	Wikidata
View/Edit Human	View/Edit Mouse

Dipeptidyl aminopeptidase-like protein 6 is a protein that in humans is encoded by the DPP6 gene.

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.