DPP3

DPP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FVY, 3T6B, 3T6J, 5E2Q, 5EHH, 5E33, 5E3C, 5E3A, 5EGY
Identifiers
Aliases	DPP3, DPPIII, dipeptidyl peptidase 3
External IDs	OMIM: 606818 MGI: 1922471 HomoloGene: 40210 GeneCards: DPP3
Gene location (Human)
Chr.	Chromosome 11 (human)
End	66,509,657 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,978,315 bp
RNA expression pattern
	Top expressed in
	oocyte; ; rectum; ; islet of Langerhans; ; secondary oocyte; ; stromal cell of endometrium; ; right adrenal gland; ; gallbladder; ; monocyte; ; body of stomach; ; gastrocnemius muscle;
	Top expressed in
	yolk sac; ; lip; ; primitive streak; ; esophagus; ; neural tube; ; lacrimal gland; ; seminal vesicula; ; renal corpuscle; ; proximal tubule; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; peptidase activity; aminopeptidase activity; protein binding; hydrolase activity; metallopeptidase activity; dipeptidyl-peptidase activity; metal ion binding;
Cellular component	plasma membrane; extracellular exosome; cytoplasm; nuclear speck; cytosol;
Biological process	proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	10072
	75221
	ENSG00000254986
	ENSMUSG00000063904
	Q9NY33
	Q99KK7
	NM_130443; NM_001256670; NM_005700
	NM_133803; NM_001360711
	NP_001243599; NP_005691; NP_569710
	NP_598564; NP_001347640
	Wikidata
View/Edit Human	View/Edit Mouse

Dipeptidyl-peptidase 3 is an enzyme that in humans is encoded by the DPP3 gene.

This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternate transcriptional splice variants have been characterized.

Dipeptidyl-peptidase 3 has been found to act as a myocardial depressant factor. Procizumab, a specific antibody for dipeptidyl-peptidase 3, was found to improve cardiac and renal function in a mouse model of heart failure. In human studies, higher levels of circulating DPP3 protein in cardiogenic shock patients indicated a more severe disease course, with a higher risk of refractory cardiogenic shock and death.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.