DLX2

DLX2
Identifiers
Aliases	DLX2, TES-1, TES1, AW121999, Dlx-2, distal-less homeobox 2
External IDs	OMIM: 126255 MGI: 94902 HomoloGene: 3244 GeneCards: DLX2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	172,102,900 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	71,377,098 bp
RNA expression pattern
	Top expressed in
	sperm; ; ganglionic eminence; ; periodontal fiber; ; pericardium; ; Brodmann area 23; ; middle temporal gyrus; ; superior frontal gyrus; ; occipital lobe; ; stromal cell of endometrium; ; prefrontal cortex;
	Top expressed in
	medial ganglionic eminence; ; molar; ; olfactory bulb; ; hair follicle; ; enteric nervous system; ; urethra; ; female urethra; ; male urethra; ; maxillary prominence; ; suprachiasmatic nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; protein binding; single-stranded RNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleus;
Biological process	cerebral cortex GABAergic interneuron differentiation; proximal/distal pattern formation; cell differentiation; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; branching morphogenesis of a nerve; embryonic skeletal system development; multicellular organism development; odontogenesis of dentin-containing tooth; cerebral cortex GABAergic interneuron fate commitment; cartilage development; brain development; negative regulation of oligodendrocyte differentiation; forebrain neuron differentiation; embryonic cranial skeleton morphogenesis; olfactory bulb development; hippocampus development; subpallium development; negative regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of cell differentiation; negative regulation of photoreceptor cell differentiation; positive regulation of amacrine cell differentiation; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	1746
	13392
	ENSG00000115844
	ENSMUSG00000023391
	Q07687
	P40764
	NM_004405
	NM_010054
	NP_004396; NP_004396.1
	NP_034184
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein DLX-2 is a protein that in humans is encoded by the DLX2 gene.

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.

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