DFNA5

GSDME
Identifiers
Aliases	GSDME, ICERE-1, DFNA5, DFNA5, deafness associated tumor suppressor, gasdermin E
External IDs	OMIM: 608798 MGI: 1889850 HomoloGene: 3242 GeneCards: GSDME
Gene location (Human)
Chr.	Chromosome 7 (human)
End	24,757,940 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	50,240,842 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; jejunal mucosa; ; stromal cell of endometrium; ; endothelial cell; ; optic nerve; ; placenta; ; oocyte; ; secondary oocyte; ; middle temporal gyrus; ; spinal cord;
	Top expressed in
	pineal gland; ; mammillary body; ; temporal muscle; ; medial ganglionic eminence; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; vastus lateralis muscle; ; lateral geniculate nucleus; ; habenula; ; digastric muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-4,5-bisphosphate binding; cardiolipin binding;
Cellular component	cytoplasm; cytosol; plasma membrane; membrane;
Biological process	inner ear receptor cell differentiation; sensory perception of sound; positive regulation of intrinsic apoptotic signaling pathway; negative regulation of cell population proliferation; programmed cell death; cell death; positive regulation of MAPK cascade; necrotic cell death; pyroptosis; cellular response to tumor necrosis factor; cellular response to virus;
	Sources:Amigo / QuickGO
Orthologs
	1687
	54722
	ENSG00000105928
	ENSMUSG00000029821
	O60443
	Q9Z2D3
	NM_004403; NM_001127453; NM_001127454
	NM_018769
	NP_001120925; NP_001120926; NP_004394; NP_001120926.1
	NP_061239
	Wikidata
View/Edit Human	View/Edit Mouse

Non-syndromic hearing impairment protein 5 is a protein that in humans is encoded by the DFNA5 gene.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.