DDO (gene)

DDO
Identifiers
Aliases	DDO, Ddo, 5330420D20Rik, 5730402C02Rik, AI467244, DASOX, DDO-1, DDO-2, D-aspartate oxidase
External IDs	OMIM: 124450 MGI: 1925528 HomoloGene: 101531 GeneCards: DDO
Gene location (Human)
Chr.	Chromosome 6 (human)
End	110,415,562 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	40,557,843 bp
RNA expression pattern
	Top expressed in
	left ventricle; ; right ventricle; ; myocardium; ; right adrenal gland; ; left adrenal gland; ; kidney tubule; ; right lobe of liver; ; putamen; ; caudate nucleus; ; endothelial cell;
	Top expressed in
	digastric muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; triceps brachii muscle; ; soleus muscle; ; parotid gland; ; myocardium of ventricle; ; interventricular septum; ; intercostal muscle; ; substantia nigra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; FAD binding; signaling receptor binding; protein binding; D-amino-acid oxidase activity; D-aspartate oxidase activity;
Cellular component	peroxisome; peroxisomal matrix; cytosol; cytoplasm;
Biological process	insemination; grooming behavior; aspartate metabolic process; D-amino acid metabolic process; hormone metabolic process; aspartate catabolic process; D-amino acid catabolic process; cellular nitrogen compound metabolic process; protein targeting to peroxisome;
	Sources:Amigo / QuickGO
Orthologs
	8528
	70503
	ENSG00000203797
	ENSMUSG00000063428
	Q99489
	Q922Z0
	NM_003649; NM_004032
	NM_027442; NM_001316716; NM_001316717; NM_001316718; NM_001316719
NP_004023; NP_001355099; NP_001355100; NP_001355101; NP_001355102;
	NP_001355103; NP_001355104; NP_001359037
	NP_001303645; NP_001303646; NP_001303647; NP_001303648; NP_081718
	Wikidata
View/Edit Human	View/Edit Mouse

D-aspartate oxidase is an enzyme that is encoded by the DDO gene.

The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two (or four, according to Q99489) transcript variants encoding different isoforms have been found for this gene.

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