DAX1

NR0B1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4RWV
Identifiers
Aliases	NR0B1, AHC, AHCH, AHX, DAX-1, DAX1, DSS, GTD, HHG, NROB1, SRXY2, nuclear receptor subfamily 0 group B member 1, Dax1
External IDs	OMIM: 300473 MGI: 1352460 HomoloGene: 403 GeneCards: NR0B1
Gene location (Human)
Chr.	X chromosome (human)
End	30,309,390 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	85,239,553 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; left adrenal gland; ; islet of Langerhans; ; germinal epithelium; ; pancreatic ductal cell; ; pituitary gland; ; amygdala; ; anterior pituitary; ; hypothalamus; ; vulva;
	Top expressed in
	seminiferous tubule; ; adrenal cortex; ; ovary; ; spermatocyte; ; ventromedial nucleus; ; ganglionic eminence; ; arcuate nucleus; ; pituitary gland; ; median eminence; ; spinal ganglia;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; sequence-specific DNA binding; protein homodimerization activity; RNA binding; nuclear receptor activity; AF-2 domain binding; DNA binding; DNA hairpin binding; steroid hormone receptor activity; protein binding; transcription corepressor activity; transcription factor binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; membrane; polysomal ribosome; nucleoplasm; microtubule organizing center; nuclear speck; intracellular membrane-bounded organelle;
Biological process	sex-determination system; spermatogenesis; negative regulation of DNA-binding transcription factor activity; transcription, DNA-templated; response to immobilization stress; pituitary gland development; gonad development; Leydig cell differentiation; steroid hormone mediated signaling pathway; transcription initiation from RNA polymerase II promoter; protein localization; hypothalamus development; negative regulation of cell differentiation; male sex determination; Sertoli cell differentiation; negative regulation of intracellular steroid hormone receptor signaling pathway; regulation of transcription, DNA-templated; cell differentiation; steroid biosynthetic process; male gonad development; adrenal gland development; negative regulation of transcription, DNA-templated; intracellular receptor signaling pathway; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	190
	11614
	ENSG00000169297
	ENSMUSG00000025056
	P51843
	Q61066
	NM_000475
	NM_007430
	NP_000466; NP_000466.2
	NP_031456
	Wikidata
View/Edit Human	View/Edit Mouse

DAX1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) is a nuclear receptor protein that in humans is encoded by the NR0B1 gene (nuclear receptor subfamily 0, group B, member 1). The NR0B1 gene is located on the short (p) arm of the X chromosome between bands Xp21.3 and Xp21.2, from base pair 30,082,120 to base pair 30,087,136.

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