DACH1

DACH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1L8R
Identifiers
Aliases	DACH1, DACH, dachshund family transcription factor 1
External IDs	OMIM: 603803 MGI: 1277991 HomoloGene: 7288 GeneCards: DACH1
Gene location (Human)
Chr.	Chromosome 13 (human)
End	71,867,204 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	98,407,201 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; ganglionic eminence; ; glomerulus; ; hair follicle; ; metanephros; ; visceral pleura; ; metanephric glomerulus; ; caudate nucleus; ; jejunal mucosa; ; lower lobe of lung;
	Top expressed in
	renal corpuscle; ; left lung lobe; ; medullary collecting duct; ; vas deferens; ; hair follicle; ; pineal gland; ; Jacobson's organ; ; conjunctival fornix; ; medial ganglionic eminence; ; iris;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II general transcription initiation factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; transcription regulator complex;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by competitive promoter binding; RNA polymerase II preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; respiratory gaseous exchange by respiratory system; transcription, DNA-templated; development of primary female sexual characteristics; negative regulation of cell migration; regulation of nuclear cell cycle DNA replication; negative regulation of cell proliferation involved in contact inhibition; cell population proliferation; negative regulation of transcription, DNA-templated; negative regulation of fibroblast proliferation; negative regulation of DNA biosynthetic process; suckling behavior; multicellular organism development; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1602
	13134
	ENSG00000276644
	ENSMUSG00000055639
	Q9UI36
	Q9QYB2
	NM_004392; NM_080759; NM_080760; NM_001366712
	NM_001038610; NM_007826
	NP_004383; NP_542937; NP_542938; NP_001353641
	NP_001033699; NP_031852
	Wikidata
View/Edit Human	View/Edit Mouse

Dachshund homolog 1, also known as DACH1, is a protein which in humans is encoded by the DACH1 gene. DACH1 has been shown to interact with Ubc9, Smad4, and NCoR.

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