Cytochrome P450 reductase

POR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B1C, 3FJO, 3QE2, 3QFC, 3QFR, 3QFS, 3QFT
Identifiers
Aliases	POR, CPR, CYP450R, cytochrome p450 oxidoreductase, P450 oxidoreductase
External IDs	OMIM: 124015 MGI: 97744 HomoloGene: 725 GeneCards: POR
Gene location (Human)
Chr.	Chromosome 7 (human)
End	75,986,855 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,764,180 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right adrenal gland; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; anterior pituitary; ; right uterine tube; ; upper lobe of left lung; ; right lung; ; left uterine tube; ; islet of Langerhans;
	Top expressed in
	olfactory epithelium; ; lacrimal gland; ; right lung; ; right lung lobe; ; superior surface of tongue; ; esophagus; ; brown adipose tissue; ; kidney; ; gallbladder; ; left lobe of liver;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	FMN binding; NADPH-hemoprotein reductase activity; flavin adenine dinucleotide binding; cytochrome-b5 reductase activity, acting on NAD(P)H; protein binding; NADP binding; electron transfer activity; enzyme binding; oxidoreductase activity; iron-cytochrome-c reductase activity; hydrolase activity; nitric oxide dioxygenase activity;
Cellular component	integral component of membrane; membrane; intracellular membrane-bounded organelle; mitochondrion; endoplasmic reticulum; endoplasmic reticulum membrane; cytoplasm; cytosol;
Biological process	regulation of growth plate cartilage chondrocyte proliferation; nitrate catabolic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to follicle-stimulating hormone stimulus; positive regulation of smoothened signaling pathway; response to nutrient; demethylation; nitric oxide catabolic process; negative regulation of apoptotic process; positive regulation of monooxygenase activity; negative regulation of lipase activity; internal peptidyl-lysine acetylation; regulation of cholesterol metabolic process; cellular response to peptide hormone stimulus; fatty acid oxidation; positive regulation of chondrocyte differentiation; cellular organofluorine metabolic process; flavonoid metabolic process; positive regulation of cholesterol biosynthetic process; positive regulation of steroid hormone biosynthetic process; cellular response to gonadotropin stimulus; carnitine metabolic process; xenobiotic metabolic process; electron transport chain; response to hormone;
	Sources:Amigo / QuickGO
Orthologs
	5447
	18984
	ENSG00000127948
	ENSMUSG00000005514
	P16435
	P37040
	NM_000941; NM_001367562
	NM_008898
NP_000932; NP_001354491; NP_001369584; NP_001369586; NP_001369587;
	NP_001369588; NP_001369591
	NP_032924
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome P450 reductase (also known as NADPH:ferrihemoprotein oxidoreductase, NADPH:hemoprotein oxidoreductase, NADPH:P450 oxidoreductase, P450 reductase, POR, CPR, CYPOR) is a membrane-bound enzyme required for electron transfer from NADPH to cytochrome P450 and other heme proteins including heme oxygenase in the endoplasmic reticulum of the eukaryotic cell.

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