Cytidine deaminase

CDA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MQ0
Identifiers
Aliases	CDA, CDD, cytidine deaminase
External IDs	OMIM: 123920 MGI: 1919519 HomoloGene: 1352 GeneCards: CDA
Gene location (Human)
Chr.	Chromosome 1 (human)
End	20,618,903 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	138,095,303 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; bone marrow; ; right lobe of liver; ; spongy bone; ; bone marrow cells; ; rectum; ; gums; ; spleen; ; skin of abdomen;
	Top expressed in
	duodenum; ; kidney; ; intestinal villus; ; jejunum; ; proximal tubule; ; facial motor nucleus; ; islet of Langerhans; ; placenta; ; yolk sac; ; left lobe of liver;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; nucleoside binding; cytidine deaminase activity; zinc ion binding; metal ion binding; protein binding; catalytic activity; identical protein binding; hydrolase activity;
Cellular component	cytosol; extracellular region; secretory granule lumen; tertiary granule lumen; ficolin-1-rich granule lumen;
Biological process	cytosine metabolic process; pyrimidine nucleoside salvage; cell surface receptor signaling pathway; cytidine deamination; negative regulation of cell growth; pyrimidine-containing compound salvage; negative regulation of nucleotide metabolic process; protein homotetramerization; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	978
	72269
	ENSG00000158825
	ENSMUSG00000028755
	P32320
	P56389
	NM_001785
	NM_028176
	NP_001776
	NP_082452
	Wikidata
View/Edit Human	View/Edit Mouse

Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene.

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. Most cytidine deaminases act on RNA, and the few that act on DNA require ssDNA.

A related activation-induced (cytidine) deaminase (AID) regulates antibody diversification, especially the process of somatic hypermutation.

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