Cysteinyl leukotriene receptor 1

CYSLTR1
Identifiers
Aliases	CYSLTR1, CYSLT1, CYSLT1R, CYSLTR, HMTMF81, cysteinyl leukotriene receptor 1
External IDs	OMIM: 300201 MGI: 1926218 HomoloGene: 4837 GeneCards: CYSLTR1
Gene location (Human)
Chr.	X chromosome (human)
End	78,327,691 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	105,647,285 bp
RNA expression pattern
	Top expressed in
	monocyte; ; superficial temporal artery; ; bone marrow; ; lymph node; ; blood; ; palpebral conjunctiva; ; Achilles tendon; ; gallbladder; ; rectum; ; spleen;
	Top expressed in
	sciatic nerve; ; carotid body; ; mucosa of small intestine; ; ankle; ; white adipose tissue; ; yolk sac; ; ileum; ; abdominal wall; ; esophagus; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled peptide receptor activity; G protein-coupled receptor activity; leukotriene receptor activity; signal transducer activity; protein binding; galanin receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane;
Biological process	defense response; positive regulation of cytosolic calcium ion concentration; respiratory gaseous exchange by respiratory system; chemotaxis; phospholipase C-activating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; leukotriene signaling pathway; circulatory system process; neuropeptide signaling pathway; calcium ion transport; signal transduction; inflammatory response to antigenic stimulus; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10800
	58861
	ENSG00000173198
	ENSMUSG00000052821
	Q9Y271
	Q99JA4
	NM_006639; NM_001282186; NM_001282187; NM_001282188
	NM_001281859; NM_001281862; NM_021476
	NP_001269115; NP_001269116; NP_001269117; NP_006630
	NP_001268788; NP_001268791; NP_067451
	Wikidata
View/Edit Human	View/Edit Mouse

Cysteinyl leukotriene receptor 1, also termed CYSLTR1, is a receptor for cysteinyl leukotrienes (LT) (see cysteinyl leukotrienes). CYSLTR1, by binding these cysteinyl LTs (CysLTs; viz, LTC4, LTD4, and to a much lesser extent, LTE4) contributes to mediating various allergic and hypersensitivity reactions in humans as well as models of the reactions in other animals.

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