Cyclin-dependent kinase 4

CDK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2W96, 2W99, 2W9F, 2W9Z, 3G33, 5FWL, 5FWM, 5FWK
Identifiers
Aliases	CDK4, CMM3, PSK-J3, cyclin-dependent kinase 4, cyclin dependent kinase 4
External IDs	OMIM: 123829 MGI: 88357 HomoloGene: 55429 GeneCards: CDK4
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,756,013 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; stromal cell of endometrium; ; right adrenal gland; ; smooth muscle tissue; ; left adrenal gland; ; left uterine tube; ; canal of the cervix; ; myometrium; ; anterior pituitary; ; pancreas;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; cyclin-dependent protein kinase holoenzyme complex; nuclear membrane; membrane; transcription regulator complex; bicellular tight junction; nucleoplasm; nucleolus; perinuclear region of cytoplasm; chromatin; nucleus; cyclin D2-CDK4 complex; protein-containing complex;
Biological process	phosphorylation; response to testosterone; positive regulation of fibroblast proliferation; response to hyperoxia; positive regulation of translation; regulation of cell cycle; cell division; protein phosphorylation; lens development in camera-type eye; regulation of cell population proliferation; response to lead ion; circadian rhythm; animal organ regeneration; positive regulation of cell population proliferation; positive regulation of cell size; positive regulation of apoptotic process; regulation of gene expression; cell cycle; positive regulation of G2/M transition of mitotic cell cycle; response to toxic substance; positive regulation of cell cycle; signal transduction; multicellular organism development; response to organic substance; cellular response to insulin stimulus; regulation of multicellular organism growth; regulation of insulin receptor signaling pathway; regulation of lipid biosynthetic process; regulation of lipid catabolic process; adipose tissue development; cellular response to lipopolysaccharide; cellular response to interleukin-4; cellular response to phorbol 13-acetate 12-myristate; cellular response to ionomycin; transcription initiation from RNA polymerase II promoter; G1/S transition of mitotic cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	1019
	12567
	ENSG00000135446
	n/a
	P11802
	P30285
	NM_052984; NM_000075
	NM_009870; NM_001355005
	NP_000066
	NP_034000; NP_001341934
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene. CDK4 is a member of the cyclin-dependent kinase family.

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