Cope reaction

The Cope reaction or Cope elimination, developed by Arthur C. Cope, is the elimination reaction of an N-oxide to an alkene and a hydroxylamine.

Cope reaction
Named after Arthur C. Cope
Reaction type Elimination reaction
Identifiers
Organic Chemistry Portal cope-elimination
RSC ontology ID RXNO:0000539

Typically, the amine oxide is prepared from the corresponding amine with a peroxy acid or comparable oxidant. The actual elimination requires just heat.

Illustrative is a synthesis of methylenecyclohexane:

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