Cope reaction
The Cope reaction or Cope elimination, developed by Arthur C. Cope, is the elimination reaction of an N-oxide to an alkene and a hydroxylamine.
Cope reaction | |
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Named after | Arthur C. Cope |
Reaction type | Elimination reaction |
Identifiers | |
Organic Chemistry Portal | cope-elimination |
RSC ontology ID | RXNO:0000539 |
Typically, the amine oxide is prepared from the corresponding amine with a peroxy acid or comparable oxidant. The actual elimination requires just heat.
Illustrative is a synthesis of methylenecyclohexane:
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